Modavigil – a good drug of a new generation

What is Modavigil and why is it used?

Modavigil (also famous under such commercial trade names as Provigil, Modafinil, Alertec and Modalert) is a psycho stimulant that improves memory and brightens the mood. It enhances the state of wakefulness, attention capacity, but its pharmacological profile is obviously different from the class of amphetamines, methylphenidate or cocaine. When taking Generic Modavigil, there is a less possibility of having jitteriness, anxiety, there will be no excess of locomotor activity leading to a hypersomnolent effect than our traditional stimulants might cause.

Subjectively, it feels much smoother and quite cleaner than, for example, the drugs of amphetamine class too. The drug may be even anxiolytic. The usual period of elimination half-life of the drug from the human body is between twelve or fifteen hours. So it's really worth fine-tuning your dosage schedule according to this fact. Present research suggests that the medication is a safe, quite efficient and well-treated substance. It acts for quite a long time and doesn't seem to be a reason of peripheral sympathetic stimulation. Its CNS action has not been fully studied yet.

Modavigil produces the state of wakefulness in part due to its participation in the anterior hypothalamus. Its dopamine-releasing effect is quite weak and depends on the dosage; the possibility of a euphoric response (potential for abuse), dose-expansion and tolerance is this way apparently small. Antagonism of the dopamine D1 and D2 receptors fully prevents drug-produced arousal. The drug has central alpha 1-adrenergic agonist special effects. That is, the substance directly promotes the receptors. The medication suppresses the reuptake of noradrenaline on neurons promoting sleep of ventrolateral preoptic nucleus.

However, even more important is its ability to enhance excitatory glutamatergic transfer. The drug reduces local GABAergic transfer, thereby diminishing GABA receptor and signalling on the mesolimbic dopamine terminals.   As the medication is often used off label, if you want to buy Modavigil for your own goals, you can do it at the nearest drugstore in the US, Australia and countries of Europe or order Modavigil at reliable online pharmacies.

Is Modavigil efficient by the treatment of different sleep disorders?

Modavigil is clinically proved to be quite useful in the treatment of narcolepsy, a famous neurological disorder characterized by uncontrollable sudden attacks of unreasonable sleepiness during the day. Narcolepsy is usually caused by dysfunction of a group of peptides that promote wakefulness and suppress the need for sleep, called orexins. Orexin neurons are usually activated exactly by the given medication.  Orexinergic neurons are situated exclusively in the lateral hypothalamic area so their activation is related to increased seeking for pleasure and motivation.

Experimentally, Modavigil is also widely used by the treatment of Alzheimer's disease; cases of severe depression; attention-deficit disorders; dystrophy; multiple sclerosis, tiredness; post-anaesthesia cognitive impairment in schizophrenia, idiopathic hypersomnia; methamphetamine abuse; apathy in the elderly; jet-lags; tiredness in Charcot-Marie-Tooth Disease and Kleine Levin syndrome. Skeptics assume the comparable therapeutic equivalence of a cup of coffee.    There is also profound evidence that Modavigil may be neuroprotective in fighting the "dopamine-deficiency disorder" by Parkinson's disease.

Depressive people who often feel sleepy and tired can increase their regimen with the usage of this medication. The USA military are also very interested in properties of the given drug too. Modavigil was repeatedly used by combat soldiers in both Gulf Wars. It is used experimentally by the treatment of so-called "atypical" depression. This variety of depression is usually characterized by hypersomnia, over-eating, too low energy, and rejection of your sensitivity. This syndrome is quite common for many people. The total results of preliminary researches have been promising, but large-scale trials are still needed.

More generally, Modavigil is widely used as a 'lifestyle drug'. Some doctors prescribing the drug to the patients have repeatedly been surprised at a hidden previously epidemic of narcolepsy among very hard-working young people that attend their hospitals. Increasing number of students use the drug when preparing for exams. The benefits of the drug as a "psycho stimulant" are the best. However, its reception at a couple of leading British universities is a usual thing among students looking for good points in exams, while drug-testing is not carried yet.